Journal of Pharmacy Tiara Bunda (JPTB) is a reputable and esteemed peer-reviewed academic publication focused on pharmaceutical sciences and related disciplines. This esteemed journal serves as a platform for researchers, academics, and professionals within the pharmaceutical field to share their innovative findings and contribute to the advancement of pharmaceutical knowledge and practices. The journal encompasses a broad range of topics, including pharmaceutical chemistry, pharmacology, pharmaceutical technology, pharmacokinetics, pharmaceutics, pharmaceutical analysis, drug development, clinical pharmacy, and other crucial aspects of pharmaceutical research and practice. Journal Title : Journal of Pharmacy Tiara Bunda Initials : JPTB Frequency : February And August E-ISSN : 3032-3657 (30323657/II.7.4/SK.ISSN/02/2024) Editor in Chief : apt. La Malihi, S.Far., M.Farm DOI Prefix : 10.62619 Publisher : Politeknik Tiara Bunda Accreditation :
ANALISA DRUG RELATED PROBLEM PADA ENDOMETRIOSIS DI PUSKESMAS DUREN SERIBU PERIODE 1 JANUARI - 30 JUNI 2025
This study analyzed the incidence of drug-related problems, including adverse events and medical errors, and possible associated risk factors, in patients with endometriosis who used combined oral contraceptives (COCs) and progestins. Reports were collected between January 1, 2024, and June 30, 2025, regarding endometriosis patients in the Medical Record System at the Duren Seribu Community Health Center, Depok City. A disproportionate analysis was performed using the Gamma–Poisson Shrinker model to detect overreported drug–event pairs. Logistic regression analysis was used to explore potential risk factors. There were 23 reports regarding long-term hormonal treatment and 45 reports regarding other medications used for endometriosis. Long-term hormonal treatment included: 15 reports (22.0%) of combined oral contraceptives (COCs), 10 reports (14.7%) of oral progestins, 8 reports (11.76%) of injectable (depot) progestins, 23 reports (33.82%) of progestin-releasing IUDs, and 12 reports (17.64%) of progestin-only implants. Both combined oral contraceptives (COCs) and progestin-only products are relatively safe for patients with endometriosis. Combination therapy (polytherapy) has been negatively associated with several medical errors in COC users, while patients aged ≥30 years have had more pulmonary embolism cases but fewer reported product-related problems.
Copyright (c) 2025 Rahayu Mustika Sari, Niati Ambarsari https://creativecommons.org/licenses/by-sa/4.0
ANALISIS POLIFARMASI SERTA HUBUNGAN POTENSI INTERAKSI OBAT TERHADAP GLUKOSA PASIEN GERIATRI
Diabetes mellitus is achronic metabolic disease that requires long-term treatment. Elderly people with multimorbidity often use multiple medications, known as polypharmacy, which can increase the risk of drug interactions. This study aims to analyze polypharmacy prescriptions and determine the relationship between drug interactions and blood glucose levels in geriatric patients with type2 diabetes. This study is non-experimental with a descriptive-analytical design through a retrospective cross-sectional approach. Sampling used random sampling in the form of medical records of171 geriatric patients with type 2 diabetes. Using univariate and bivariate analysis in the form of chi-square statistical tests with a significance level of<0.05. The results showed that the incidence of type 2 diabetes in geriatric women was higher than in men at119 (69.59%), with the largest distribution of geriatric patients in the 60-69 year age range (77.77%). Based on polypharmacy prescriptions, the most common type of polypharmacy encountered was minor polypharmacy (5-9 drugs)(95.3%), and 159 patients (92.98%) had the potential for interactions. Based on the mechanism pattern, pharmacodynamic interactions occurred in413 cases (74.95%), with the most common level of interaction severity being moderate, occurring in340 cases (61.7%). Chi-square test results showed a relationship between potential drug interactions and blood glucose levels, with p-value of 0.000<0.005.
Copyright (c) 2025 Hasna Dewi, Lukidita Agustiansyah, Dian Andini https://creativecommons.org/licenses/by-sa/4.0
HUBUNGAN TINGKAT PENDIDIKAN DENGAN PERILAKU PENGGUNAAN OBAT RASIONAL
This study analyzes the correlation between education level and rational drug use behavior among communities in East Jakarta. The objective was to determine whether higher levels of education are associated with better understanding and implementation of rational drug use. A cross‑sectional design was employed using structured questionnaires and simple random sampling. The results showed a significant positive relationship between education level and rational drug use practices. Respondents with higher education demonstrated better knowledge, attitudes, and behavior in using medicines appropriately. These findings highlight the importance of health education and literacy programs to improve rational drug practices in the community
Copyright (c) 2025 Amir Kemal Sidiq https://creativecommons.org/licenses/by-sa/4.0
ANALISIS PENAMBATAN SENYAWA CHARANTIN DARI BUAH PARE (Momordica charantia) PADA GLUCOSE TRANSPORTER 3 (GLUT3)
Glucose transporters have an important role in the body to transport blood sugar to other organs. In patients with diabetes mellitus, the signaling of GLUT, especially class 1, is reduced because it is affected by impaired insulin secretion. Bitter gourd is thought to have an anti-diabetic effect by lowering blood pressure, with the main component in it being charantin. Purpose: This study aims to determine the activity of charantin as a blood sugar lowering agent by inducing GLUT3 through a compound anchoring test. Methods: The type of research in this study was a computer-based experimental study using an in silico test or molecular docking by comparing the charantin test ligand and the native ligand as a comparison in the form of Octyl Glucose Neopentyl Glycol. Conclusion: The results of the compound anchoring test show that the binding energy (ΔG) affinity of charantin for GLUT3 is -7.5 Kcal/mol, while for Octyl Glucose Neopentyl Glycol it is -6.15 Kcal/mol, and charantin has activity like Octyl Glucose Neopentyl Glycol with amino acid residues that bind to the active site of the GLUT3 protein, namely AGR228. This indicates that the compounds present in bitter gourd can be predicted to be used as therapy for diabetes mellitus patients.
Copyright (c) 2025 Nisrien Ilmia https://creativecommons.org/licenses/by-sa/4.0
SKRINING FITOKIMIA DAN UJI AKTIVITAS ANTIBAKTERI EKSTRAK DAUN KAPUK (CEIBA PENTANDRA (L.) GAERTN) TERHADAP BAKTERI ESCHERICIA COLI
ABSTRAK Kapuk (Ceiba pentandra (L.) Gaertn) merupakan salah satu tanaman asli Indonesia yang sudah dikenal sejak lama. Diketahui kandungan senyawa aktif dalam daun kapuk diyakini mengatasi demam, diare, diabetes, hipertensi, sakit kepala, obat luka, dan astringen ( menyerap air ) yang dapat membantu menghentikan diare Banyak manfaat yang dirasakan oleh masyarakat dengan adanya tanaman obat, bahkan tanaman obat dapat menjadi salah satu alternatif yang dapat menyebuhkan berbagai macam penyakit yang sangat ekonomis. Penelitian bertujuan untuk mengetahui kandungan fitokimia ekstrak etanol daun kapuk dan pengaruh berbagai konsentrasi ekstrak etanol dau kapuk terhadap pertumbuhan bakteri E-coli. Metode kerja yang digunakan yaitu pembuatan simplisia, ekstraksi, skrining fitokimia, pengujian aktivitas antibakteri berdasarkan diameter zona hambat menggunakan metode difusi cakram. Berdasarkan dari hasil penelitian yang telah dilakukan bahwa ekstrak daun kapuk mempunyai kandungan senyawa metabolit sekunder yang memiliki aktivitas antibakteri, seperti: alkaloid, flavonoid, tanin, dan saponin. Ekstrak daun kapuk juga memiliki kemampuan antibakteri terhadap bakteri E-coli yang diperolehnya nilai kategori lemah. Pada konsentrasi 20 %, 40 %, 50 %, dan nilai kontrol positif nilai konsentrasi hambat minimum pada ekstrak daun kapuk ditemukan. Sedangkan, pada nilai kontrol negatif tidak ditemukan.
Copyright (c) 2025 Dhea Regita https://creativecommons.org/licenses/by-sa/4.0
FORMULASI DAN EVALUASI SEDIAAN KOSMETIK LIP BALM DARI EKSTRAK DAUN PACAR AIR (IMPATIENS BALSAMINA L.)
Bibir sangat rentan terhadap pengaruh lingkungan serta berbagai produk perawatan kesehatan, kosmetik dan produk produk perawatan kulit lainnya yang dapat menyebabkan kerusakan kulit bibir yaitu bibir menjadi kering dan pecahpecah juga menimbulkan rasa nyeri dan tidak nyaman. Untuk menyembukan penyakit bibir seperti pecah atau kering dan agar terlihat lebih lembab maka dibutuhkan pengobatan salah contohnya adalah ekstrak daun pacar air yang diformulasi dalam bentuk lip balm. Penelitian ini bertujuan untuk mengetahui bahwa ekstrak daun pacar air (Impatients balsamina L) bisa dapat dimanfaatkan sebagai pewarna alami pada sediaan lip balm. Simplisia pada daun pacar air diekstrak menggunakan metode maserasi dengan pengujian skrining fitokimia dan uji evaluasi sediaan lip balm. Hasil yang diperoleh pada penelitian bahwa ektrak daun pacar air bisa dijadikan pewarna alami pada sediaan lip balm dan hasil formulasi F1,F2,dan F3 yang menghasilkan formulasi yang paling baik adalah F3 dengan konsentrasi sebesar 15 %
Analisis Tingkat Kepuasan Pelanggan Terhadap Pelayanan Kefarmasian Model SERVQUAL di Apotek X Kota Belitang
Pelayanan kefarmasian di apotek merupakan tolok ukur mutu pelayanan kesehatan yang diberikan. Kepuasan pelanggan menjadi indikator penting dalam evaluasi dan perbaikan mutu pelayanan. Penelitian ini bertujuan mengetahui tingkat kepuasan pelanggan terhadap pelayanan kefarmasian di apotek berdasarkan lima dimensi SERVQUAL: kehandalan, ketanggapan, empati, jaminan, dan bukti fisik. Penelitian ini menggunakan metode deskriptif kuantitatif dengan teknik quota sampling pada 82 pelanggan yang berkunjung pada Juni–Juli 2024 dan memenuhi kriteria inklusi. Data dikumpulkan menggunakan kuesioner skala Likert dan dianalisis secara univariat. Hasil penelitian menunjukkan bahwa pelanggan merasa sangat puas pada semua dimensi: kehandalan (4,58), ketanggapan (4,55), empati (4,41), jaminan (4,40), dan bukti fisik (4,65), dengan skor rata-rata keseluruhan 4,40 (kategori puas). Hasil ini menunjukkan bahwa mutu pelayanan di apotek tergolong baik, namun peningkatan pada dimensi empati dan jaminan tetap diperlukan untuk lebih meningkatkan pengalaman pelanggan.
kepuasan pelanggan; pelayanan kefarmasian; SERVQUAL; apotek komunitas
Copyright (c) 2025 Ahmad Subagiyo https://creativecommons.org/licenses/by-sa/4.0
Perbandingan Efektivitas Paracetamol dan Ibuprofen untuk Terapi Penurun Demam pada Usia 6 Bulan sampai 18 Tahun di RSUD Kota Depok periode Juni 2023 sampai Juni 2024
Fever has been noted as a precursor or characteristic of the disease. Conditions that aggravate fever often result in therapeutic failure or a poor prognosis. This study aims to analyze the comparison of single therapy administration of Paracetamol, Ibuprofen and a combination of both in treating fever and/or pain in patients aged 6 months to 18 years. The results of the study showed that using Ibuprofen alone was better at reducing fever in the first 4 hours than Paracetamol alone, however, the combination therapy of the two was not much different from using Ibuprofen alone. To treat pain accompanied by fever, using Ibuprofen alone has been proven to provide a longer pain-free period compared to using Paracetamol alone, and the combination of the two is not much different from Ibuprofen
Journal of clinical pharmaceutical sciences
Copyright (c) 2024 Mustika Rahayu, Niati Ambarsari, Nur Fadilah https://creativecommons.org/licenses/by-sa/4.0
POTENSI BAHAN ALAM BAWAH LAUT SEBAGAI OBAT ALAMI UNTUK PENGOBATAN DIABETES
The potential of underwater natural materials has attracted the attention of researchers and health professionals as an effective source of natural remedies for the treatment of diabetes. Several examples of polyphenol compounds found in underwater natural materials have the ability to act as antioxidants, so they are widely used to improve the condition of diabetic patients. Polyphenols have the ability to suppress postprandial hyperglycemia by inhibiting the hydrolysis activity of enzyme carbohydrates, inhibiting glucose transport in the blood, affecting the function of cells β pancreas, and glucose absorption tissue. The method used in this writing is literature review using international and national journals that are in accordance with the purpose of writing. Thus, the potential of underwater natural ingredients as a natural remedy for diabetes treatment is very promising and needs to be further examined and developed to improve the quality of life of diabetics.
Natural ingredients; diabetes; natural medicine; medicine
Copyright (c) 2024 Putri Agustina https://creativecommons.org/licenses/by-sa/4.0
THE INFLUENCE OF ELECTRONIC PRESCRIPTIONS ON PRESSRIBING ERROR IN THE CLINIC X JAKARTA PHARMACY INSTALLATION
Electronic prescriptions play a role in preventing medication errors, which means failures in the treatment process that have the potential to result in harm and endanger the patient. Prescribing errors are errors in drug selection, such as errors in dosage, quantity, indications and contraindications for treatment. This study aims to determine the effect of electronic prescriptions on prescribing errors in improving pharmaceutical services at clinic X Jakarta. The research method used was descriptive research with a random sampling technique, using 250 electronic prescriptions and 250 manual prescriptions in January – May 2023. The results of the study showed prescribing errors in electronic prescriptions, namely 15 prescriptions (no dose (2%), incorrect instructions). usage (2%), no dosage form(2%)). In manual prescriptions, 41 prescribing errors occurred (unclear writing (2%), no patient name (2%), no weight (1.6%), no medication dose (2.8%), no exact instructions for use (2%), no dosage form (2%), no patient age (4%), no prescription date (2%)). The conclusion from this research is that the use of electronic prescriptions in clinic X Jakarta has a very big influence on prescribing errors. Of the 250 manual prescriptions and 250 electronic prescriptions, the largest prescribing error was found, namely 41 prescriptions (18.40%) for manual prescriptions, while only 15 prescription errors for electronic prescriptions (6%).
Elektronic prescription; prescribing error; Pharmacy installation
Copyright (c) 2024 Niati Ambarsari, Ni Kadek Dwi Parwati https://creativecommons.org/licenses/by-sa/4.0
Skrining Fitokimia dan Uji Aktivitas Antioksidan dengan Metode DPPH Ekstrak Benalu Pohon Mahoni (Loranthus sweietenia macrophylla)
Mahogany tree (Swietienia macrophylla king) has many benefits as an antioxidant, starting from the roots, bark, leaves, even the mistletoe that lives on this plant. Mahogany mistletoe leaves (Loranthus swietenia macrophylla) were used as samples in this study to test their antioxidant activity. This study was conducted because many have conducted antioxidant tests on mistletoe leaves such as mengkudu mistletoe leaves, coffee mistletoe leaves, mango mistletoe leaves and kersen mistletoe leaves. Mahogany mistletoe leaves (Loranthus swietenia macrophylla) were used as samples in this study to test their antioxidant activity. Before the antioxidant activity test was carried out, a phytochemical screening test was first carried out as a qualitative analysis stage to determine the secondary metabolite content in mahogany mistletoe leaves. Mahogany mistletoe leaves were dried in variations of 0 days (S), 4 days (KA4), and 8 days (KA8) which were extracted by maceration with 96% ethanol solvent. The results of the phytochemical screening test showed that mahogany mistletoe leaf extract contains secondary metabolite compounds such as flavonoids, phenolics, alkaloids, saponins, terpenoids, and steroids. The total phenolic content was 25.25; 48.29; and 52.82 mgGEA/g extract for extracts S, KA4, and KA8, respectively. Furthermore, the antioxidant activity test using vitamin C as a comparator with the DPPH (2,2-Diphenyl-1-picrylhydrazyl) method showed IC50 values ​​of 10.79; 8.00; 7.41 ppm for extracts S, KA4, and KA8, respectively, indicating that the highest antioxidant activity was possessed by sample KA 8 with an IC50 value of 7.41 ppm with a total phenolic content of 52.82 mgGEA/g
Copyright (c) 2023 Mila Oktaviani https://creativecommons.org/licenses/by-sa/4.0
Uji Aktivitas Antibakteri Ekstrak Daun Kemangi (Ocium sanctum L) terhadap bakteri Patogen dengan metode KLT Bioautografi
A research of the antibacterial activity test extracts of basil (Ocimum sanctum L) against pathogenic bacteria by using KLT Bioautografi. This study aims to determine the activity and basil leaf extract chemical components are on the inhibition of bacterial. Basil (Ocimum sanctum L) extracted by maceration method using ethanol 70%. Extraction then screened for antibacterial activity with levels of 1 mg / ml against microbes that Staphylococcus aureus, Streptococcus mutans, Staphylococcus epidermidis, Salmonella typhi, Bacillus subtillis, Escherichia coli, Pseudomonas aeruginaosa and vibrio sp. Tests showed that 70% ethanol extract of leaves of basil can inhibit the growth of Staphylococcus aureus, Streptococcus mutans, Salmonella typhi, Bacillus subtillis, Escherichia coli, Pseudomonas aeruginaosa and vibrio coma. Testing TLC-Bioautografi basil leaves ethanol extract using ethyl acetate eluent: n-hexane (1: 3) showed inhibition of bacteria at Rf values of 0.15, 0.31, 0.44. Identification test showed that the compounds provide antibacterial flavonoids, alkaloids and terpenoids
Copyright (c) 2023 Hasna Dewi https://creativecommons.org/licenses/by-sa/4.0
Skrining Aktivitas Antibakakteri Fraksi Kulit Buah Durian (Durio zibhetimus M)
A screening study of antibacterial activity of Durio zibethinus M fraction on Escherhicia coli bacteria and Staphylococcus aureus bacteria has been carried out. This study aims to determine the inhibitory effect of durian peel extract on Escherhicia coli bacteria and Staphylococcus aureus bacteria, to determine the most active fraction in inhibiting the growth of Escherhicia coli bacteria and Staphylococcus aureus bacteria and to find out the most active class of compounds against antibacterial activity.The fraction on Duiro zibethinus M was carried out by vacuum liquid chromatography method..Ethyl acetate and methanol extract have antibacterial activity characterized by the presence of clear inhibition zones in the paper disk area, for n-hexane extract does not have a inhibitory effect on bacteria. The results of the inhibition of ethyl acetate extract, which is 17.13 mm are strongly marked for Escherichia coli bacteria and moderate inhibitory capacity of 7.34 mm for Staphylococcus aureus bacteria. Whereas the inhibitory results of methanol extract were 15.11 mm which means that it is strong for Escherichia coli bacteria and strong inhibition power of 11.45 mm for Staphylococcus aureus bacteria. Fraction 2 has antibacterial activity in Staphylococcus aureus bacteria characterized by the presence of clear inhibition zones in the piper disk area, whereas in Escherichia coli bacteria there is no inhibiting fraction. The results of the inhibition of fraction 2 is 9.96 mm which means that it is medium for Staphylococcus aureus bacteria. On the results of identification fractionation of Durio zibethunus M fruit skin showed function as an antibacterial, namely the Flavonoid compound
: Durian Fruit Skin; Vacuum Liquid Chromatography; Escherhicia coli; Staphylococcus aureus
Copyright (c) 2023 Amir Kemal https://creativecommons.org/licenses/by-sa/4.0
Formulasi dan Uji Stabilitas Fisik Sediaan Salep Dari Fraksi Daun Kemangi (Ocimun sanctum L)
This basil plant (Ocimum Sanctum.Lin.) contains: essential oils, alkaloids, eugenol, rosmarinic acid, saponins, flavonoids, tannins and phenols. This study aims to determine the preparation of ointment from the basil leaf fraction that meets the requirements of the physical quality of the preparation and to determine the effect of variations in the ointment base from basil leaves by testing the physical stability of the preparation. This research was conducted using the one-way Anova statistical test followed by the Tukey test and the data were analyzed using Kurskal Wallis and Man Withney then tested for the physical properties and stability of the ointment which included organoleptic tests, homogeneity tests, pH tests, viscosity tests, dispersibility tests, and adhesion test. The results showed that basil leaf extract could be formulated into ointment preparations from the basil leaf fraction (Ocimum Sanctum L) into ointment preparations with various base variations that met the physical quality requirements of the preparation and in this study there was an effect of variations in the ointment base from the basil leaf fraction ( hydrocarbon base, absorption base and water soluble base) based on the physical stability test of the ointment preparation. So it can be concluded that the Basil leaf extracts and fractions can be formulated into ointment preparations (Ocimum Sanctum L) but do not meet the physical quality requirements of the preparation and have the effect of base variations on the ointment preparation
Ocimum Sanctum.L; ointment; basil leaf fraction
Copyright (c) 2023 Rahayu Mustika Sari https://creativecommons.org/licenses/by-sa/4.0
Pengetahuan dan Rasionalitas Pasien Terhadap Pengobatan Sendiri di Apotek
knowledge about self-medication. This sampling was carried out using the Purposive Sampling method, namely a sampling determination technique based on certain considerations. Data collection took place for two months using a questionnaire instrument as data collection for 90 respondents. Through the primary data obtained in the form of questions distributed to respondents who came to buy medicine at the Pharmacy. The data obtained by collecting the answers to the questionnaire were then tabulated, scored, and presented. Based on the results of the study, it was concluded that the level of public knowledge about self-medication in three Pharmacies, which stated that they knew 77.19%, did not know 14.67%, and did not know 8.12%. So it was concluded that the level of public knowledge about self-medication was included in the high category, namely 77.19%
Level of Knowledge, Self-medication, Pharmacy;
Copyright (c) 2021 Ika Aulia Rahmi https://creativecommons.org/licenses/by-sa/4.0
FORMULASI DAN UJI STABILITAS FISIK GEL HAND SANITIZER KOMBINASI EKSTRAK DAUN SIRIH HIJAU (PIPER BETLE) DAN EKSTRAK DAUN KELOR (MORINGA OLEIFERA) SEBAGAI ANTIMIKROBA
Antiseptics or handsanitizers generally contain alcohol and triclosan which when used continuously can irritate the skin, causing a burning sensation on the skin. One alternative to reduce the chemical content in handsanitizers is to use natural ingredients that contain antimicrobial compounds. Natural ingredients used in this study are betel leaf extract and Moringa leaf. The purpose of this study was to determine the right combination of betel and moringa leaf extract concentrations for a handsanitizer formulation with good physical stability and antimicrobial activity. This research method used a completely randomized design (CRD) with a combination of concentrations, namely FI (25% betel leaf extract and 75% moringa leaf extract), F2 (50% betel leaf extract and 50% moringa leaf extract) and F3 (75% betel leaf extract and 25% Moringa leaves). The results showed that green betel leaf and moringa leaf extracts can be made as hand sanitizer gel preparations with various combinations of concentrations. Hand sanitizer gel of green betel leaf and moringa leaf extract with a concentration of 75% betel leaf extract and 25% moringa leaf extract had the best physical properties and stability
Handsanitizer, Piper betle, Moringa oleifera, Physical stability, Antimicrobial
Copyright (c) 2022 Herlina Anggraini https://creativecommons.org/licenses/by-sa/4.0
PEMBUATAN TEH HERBAL DARI DAUN KELAPA SAWIT (ELAEIS GUINEENSIS JACQ)
Tea is one drink that is liked and consumed by people all over the world, containing tannin which is believed to be a refreshing and healthy drink. To make oil palm herbal tea, and know the quality standards bioactive components. Palm leaves are separated from the lid, washed thoroughly, drained, cut ± 1 cm. Furthermore, it is placed on a rack and allowed to wither for 14 to 24 hours, then the leaves are blended and oxidized. Then put it in a cool and humid place, for the fermentation process. Furthermore, it is dried in a drying cabinet with a temperature variation of 50 ° C, 90 ° C and 110 ° C with successive times (110, 130, and 150 minutes) then a quality standard test, and screening of herbal tea powder. Quality standard test of oil palm herbal tea smell, taste and color of distinctive brewing water of tea products, cadmium metal contamination (0.303ppm) and lead (0.149ppm), arsenic contamination (<0.0004ppm), microbial contamination with total plate number11.72 ×107,, water content in a row (7.18; 5.88; 3.92%), extract content in water (8.6; 5.96; 5.76%), total ash content (4.3;4.91; 5.26%), water soluble ash content from total ash (4.62; 7.88; 10.09%), acid insoluble ash content (0.75; 0.93 ; 1.17%). Herbal tea powder screening results were positive for triterpenes/steroids, alkaloids, flavonoids, tannins, saponins, and glycosides. The results of flavonoid test results from fresh leaves of palm oil, powder before drying, herbal tea with drying temperature variations of 50°C, 90° C and 110°C with successive times (110, 130, 150 minutes), namely (357.13;265.678; 175.14; 161.28; 176.99 mg / 100)Oil palm leaf herbal tea can be made as an herbal tea and variationsin drying temperature can affect the quality of the oil palm leaf herbal tea
herbal tea (Elaeis guineensis Jacq), herbal tea powder screening, temperature variations
Copyright (c) 2022 Lola' Tulak Rerung https://creativecommons.org/licenses/by-sa/4.0
AKTIVITAS HIPOGLIKEMI DARI TEH HERBAL CAMPURAN HERBA SAMBILOTO (Andrographis Paniculata) DAN BIJI MAHONI (Swietenia Mahagoni) DAN PROFIL METABOLIT SEKUNDER TAHUN 2022
Diabetes mellitus is a chronic metabolic disorder that continues to present a major world wide health problem. Numerous herbal drugs like Andrographis paniculata and Swietenia mahagoni have been used by people of various cultures to treat diabetes. The aim of this research was to measure the hypoglycemic activity herbal tea of Andrographis paniculata herbs and Swietenia mahagoni seeds and their combination in alloxan- induced diabetic mice. The tea was prepared by brewing 10 g herbal tea with 100 ml of boiling water for 10 minutes. The herbal tea of Andrographis paniculata herbs, Swietenia mahagoni seeds, combination with ratio 1:1, 1:2 and 2:1 (0.4 ml/20 g BW), was administered orally to groups I, II, III, IV and V respectively. The reference drug glibenclamide (0,013 mg/10 g BW) and CMC-Na were also administered orally to animals in positive and negative control group respectively. Oral administration of herbal tea for seven days resulted in a slight reduction in blood glucose level. Statistically there is no groups that has significant difference with negative control groups (P < 0.05) except positive control. Therefore the herbal tea combination of Andrographis paniculata herbs and Swietenia mahagoni seeds with ratio 2:1, showed the biggest reduction in blood glucose level (88.20 ± 43.16 mg/dl). The secondary metabolite profiling was done by establish the TLC and chromatogram profile. TLC profiling was performed out using Chloroform:Methanol (9:1) as mobile phase. Then, TLC plate scanned in wavelength 254 nm and 366 nm using CAMAG TLC Scanner 3.
Andrographis paniculata, Swietenia mahagoni, hypoglycemic activity, herbal tea
Copyright (c) 2022 Hasna Dewi https://creativecommons.org/licenses/by-sa/4.0
FORMULASI DAN UJI SIFAT LILIN AROMATERAPI KOMBINASI MINYAK ATSIRI DAUN KEMAFORMULASI DAN UJI SIFAT LILIN AROMATERAPI KOMBINASI MINYAK ATSIRI DAUN KEMANGI (OCINUM SANCTUM L) DAN SEREH (CYMPOGOGON ATRATUSNGI (OCINUM SANCTUM L) DAN SEREH (CYMPOGOGON ATRATUS)
In the current conditions of the Covid-19 pandemic, aromatherapy candles have become a necessity for the community as an alternative treatment by utilizing natural ingredients whose popularity is increasing. One of natural ingredients used for aromatherapy is basil and lemongrass. This study aimed to determine whether the essential oil combination of basil leaves (Ocimum sanctum L) and lemongrass (Cymbopogon citratus) can be formulated into aromatherapy candles. The experiment was conducted in the laboratory. The essential oils of basil and lemongrass were gainded from E-Commerce and processed through Thin Layer Chromatography. Silica gel stationary phase, chloroform-benzene mobile phase for basil leaves and toluene-ethyl acetate mobile phase for lemongrass samples. Then the materials (for making aromatherapy candle) were made in three different concentrations of formula I (3%: 20%), formula II (2%: 10%), and formula III (1%: 5%). Test of physical properties of the materials included organoleptic test, test melting point, burn times test and preference test from 20 respondents. The results of the test of the materials for aromatherapy candle showed that there was an affect on the physical properties of aromatherapy candles. Based on the findings of physical properties test, formula III resulted the best because of high melting test point and the longest burning time. Formula I was widely preferred for greater concentration of essential oils
Basil essential oil; Lemongrass essential oil, Aromatherapy candles; Test the physical properties of the preparation
EVALUASI TINGKAT PENGETAHUAN DAN RASIONALITAS SWAMEDIKASI DENGAN KARAKTERISTIK MASYARAKAT
Self-medication is a process carried out by a person starting form the introduction of complaint or symptoms and oon the selection and use of drugs. The diseases are: fever, pain, colds and flu, cough, gastritis, diarrhea. The problem that often occurs is the lack of public knowledge rational certification. This study was conducted to evaluate the level of publik knowledge of self—medication and rationality of drug usage by providing educaton so that there is an increase in public understanding and knowlegde about good self-medication. Cross-sectional descriptive research method. Data were taken secondary through filling out the questionnaire, there were 9 people in Pengasinan Sawangan District selected by accidental sampling method. Data were processed using the statistical product and service solution (SPSS) application version 22 with a chi-square test. The results of the study stated that the level of public know ledge of 22.80% is good, 44.30% is moderate and 32.90% is poor. 70.90% of the majority of people use drigs rationlally and 29.10% are not rational. There is a relationship between age and last education with the level of knowledge andd rrationality in using self-medication drugs. However, it has nothing to do with sex and occcupation. Based on the results ot the study are that the level of public know ledge is moderate, 44.30% and the rationality of drug use is rational 70.90%
Self-medication; knowledge; Rationality of Drug
Copyright (c) 2021 Herlina Anggraini https://creativecommons.org/licenses/by-sa/4.0
FORMULASI DAN UJI SIFAT LILIN AROMATERAPI KOMBINASI MINYAK ATSIRI DAUN KEMANGI (OCINUM SANCTUM L) DAN SEREH (CYMPOGOGON ATRATUS)
Basil essential oil, Lemongrass essential oil, Aromatherapy candles, Test the physical properties of the preparation
Copyright (c) 2022 Amir Kemal https://creativecommons.org/licenses/by-sa/4.0
FORMULASI DAN UJI ANTIBAKTERI SPRAY HAND SANITIZER DARI EKSTRAK DAUN PILADANG (Plectransthus Scutellaroides (L) R.Br) TERHADAP Staphylococcus aureus
Piladang leaf (Plectranthus scutellaroides (L) R.Br) is a plant that has antibacterial activity, one of which is Staphylococcus aureus, so it can be used as an active ingredient in spray hand sanitizer or hand antiseptic spray. This study aims to formulate piladang leaf extract in the form of spray hand sanitizer and to test its antibacterial activity against Staphylococcus aureus using agar diffusion method. In this research, 3 spray hand sanitizer formulas were made with variations in the concentration of piladang leaf extract 3.5%; 7% and 10.5%. Then performed a physical stability test with test parameters including organoleptic, viscosity, homogeneity, pH, stability, irritation test and dry time test. The results showed that based on physical stability tests it was found that organoleptically, viscosity, homogeneity, pH and stability for the three formulas was stable during storage, then based on the antibacterial spray hand sanitizer test against Staphylococcus aureus, it was found that the concentration of piladang leaf extract affected the inhibition of growth of Staphylococcus aureus by showing inhibition of 15.18 mm for a concentration of 3.5%; 17.2 mm for a concentration of 7% and 22.08 mm for a concentration of 10.5%.
Plectranthus scutellaroides, Spray Hand Sanitizer, Staphylococcus aureus
TINGKAT PENGETAHUAN DAN RASIONALITAS SWAMEDIKASI MASYARAKAT
Self-medication has the potential to become a source of medication errors if the community's knowledge of drugs and their use is very limited. This study aims to determine the level of knowledge and rationality of self-medication community in Tanah Baru subdistrict, Beji district, Depok city. This research was conducted with a cross sectional d escriptive research method. Data were collected through filling out a validated online questionnaire. All of 375 respondents who was involved in this study were selected by the snowball sampling method. Data were analyzed using univariate and bivariate methods in the Statistical Product and Service Solution (SPSS) program version 18. The results showed that the level of knowledge in community 24% was good classified, 40.8% were medium classified and 35.2% were bad classified with an average score of 14.01. The use of self medicated drugs was 31.5% irrational and 68.5% rational. Based on the result of Chi-square and Fisher, the level of knowledge was influenced by recent education and job with p 0.00 and p 0.04 (p value <0.05). Meanwhile rationality of self medication was influenced by recent education with p 0.03 (p value <0.05). In addition, the level of knowledge about self-medication does not have a significant effect to rationality of self- medication. Recent education and job of community affect the level of self-medication knowledge, and the rationality of self-medication was affected by recent education. In addition, the level of self medication knowledge has no significant effect to the rationality of community self medication
Self Medication, Knowledge, Rationality of drug use, Community
Copyright (c) 2021 Putri Betania https://creativecommons.org/licenses/by-sa/4.0
PEMANFAATAN HERBAL DALAM PENYEMBUHAN LUKA BAKAR
Burns are damage to skin tissue caused by contact with sources that conduct heat. Burns can cause impaired appearance, function, patient dependence, job loss and future survival. Handling and proper treatment will avoid things that are not desirable such as infection in burns. Use the medical treatment continuous sometimes has adverse side effects, so that treatment using traditional plants is an alternative treatment. This literature study aims to determine the potential of traditional plants that can be used for healing burns obtained from published research journals. Aloe vera (L.) Burm. F., Allium ascalonicum L., Artocarpus altilis, Pandanus amaryllifolius Roxb and Piper betle Linn. are some plants that have the potential to help heal burns. The content of secondary metabolite compounds contained in it can help in healing burns such as flavonoids, alkaloids, tannins and saponins
Burns, Traditional Plants, Secondary Metabolites.
PENGARUH PANDEMI COVID-19 TERHADAP MASYARAKAT KELURAHAN TANAH BARU KECAMATAN BEJI DALAM MELAKUKAN SWAMEDIKA
Background: The COVID-19 pandemic has resulted in a tendency for people to prefer self-medication treatment than to undergo treatment in health facilities. Objective: To determine the effect of the COVID-19 pandemic on the attitude of the Tanah Baru Village community in carrying out self-medication and the influence of sociodemographic factors on attitudes towards self-medication during the COVID-19 pandemic. Methods: This research was conducted using a descriptive cross sectional research method. Data were collected through filling out a validated questionnaire. A total of 376 respondents who are residents of Tanah Baru village were selected by random sampling method. Data were analyzed using univariate and bivariate methods in the Statistical Product and Servicer Solution (SPSS) version 22 program. Results: Based on the results of the Chi-square test, the COVID-19 pandemic affected people's attitudes in performing self-medication significantly (p<0.05). The latest education has a significant influence on people's attitudes in carrying out self-medication before and during the COVID-19 pandemic (p<0.05). Conclusion: Based on the results of the study, it can be concluded that the COVID-19 pandemic affected the attitude of the people of Tanah Baru Medan Village in carrying out self-medication. The latest education affects people's attitudes in carrying out self-medication before and during the COVID-19 pandemic
Society, COVID-19 Pandemic, Attitude, Self-medication
Copyright (c) 2021 Hasna Dewi https://creativecommons.org/licenses/by-sa/4.0
TINGKAT PENGETAHUAN TENTANG ANTIBIOTIK PADA MAHASISWA POLITEKNIK TIARA BUNDA
Antibiotics are widely prescribed drugs. The relatively high and inappropriate use of antibiotics can cause various problems consequently become a global threat to health, especially due to bacterial resistance. The purpose of this study was to determine the level of students’ knowledge on the use of antibiotics and correlate between the level of knowledge of antibiotics with the frequency of using antibiotics without a prescription for students at Politeknik Tiara Bunda The study used a descriptive method with cross-sectional design. It was conducted from May to June, 2017. Respondents were 250 students from 6 faculties at Politeknik Tiara Bunda, selected by using proportional sampling technique. The results of this study showed that 52.4% of the students at Politeknik Tiara Bunda had moderate, 27.2% good and 20.4% less of knowledge about antibiotics, while the frequency of use of antibiotics without prescription at 44.8%. Chi-square test results showed that the students’ level of knowledge was affected by origin of faculty (p < 0.05), whereas gender, age and origin of place does not significantly affect the students’ level of knowledge (p > 0.05). The correlate between the pharmacy with non-pharmacy students’ knowledge was at (p < 0.05), as well as the correlate between students’ knowledge with the frequency of use of antibiotics without prescription, thus proving that there was a significant correlation between pharmacy with non-pharmacy students’ knowledge and between students’ level of knowledge with the frequency of use of antibiotics without prescription.
Antibiotics, resistance, knowledge, students
FORMULASI DAN UJI SIFAT FISIK LIP BALM ESKTRAK ETANOL BUAH STRAWBERRY (Fragraria Sp)
Lip balm is a preparation that is applied to the lips to function as a moisturizer by forming a layer of oil that does not mix on the surface of the lips. Strawberry (Fragraria) functions as an antioxidant and anti-inflammatory so that the strawberry fruit extract can be used as a moisturizer and will be maximized when used in the form of cosmetic products. The aim was to determine whether the ethanol extract of strawberry fruit (Fragraria) can be used in lip balm preparations and the difference in the ethanol extract concentration of strawberry fruit (fragraria) could affect the physical properties of lip balm preparations and determine the concentration of what lip balm preparations preferred by respondents. Strawberry fruit is obtained in the mountainous area of Tegal district. The extraction method used in this research is the maceration method with a concentration of 5%, 10% and 15%. The evaluation of lip balm preparations includes organoleptic test, pH test, irritation test, preference test, homogeneity test, smear test, melting point test. The results showed that the lip balm preparation of strawberry fruit extract (Fragraria) had no effect on the physical properties of the lip balm preparation. Formulas 1, 2 and 3 produce good physical properties, which include organoleptic tests, homogeneity tests, pH tests, melting point tests, irritation tests, and spreadability tests. Based on the preference test which includes color, aroma and moisture, formula 1 is the most preferred formula with a preference for color and aroma as much as 90% with the humidity level of 80%
Lip Balm, fragraria, Physical Properties Test
Copyright (c) 2022 Rahayu Mustika Sari https://creativecommons.org/licenses/by-sa/4.0
FORMULASI DAN EVALUASI SABUN CAIR EKSTRAK ETANOL DAUN JARAK PAGAR ( Jatropha curcas) SEBAGAI ANTIBAKTERI Staphylococcus aureus
One of the medical plants is Jatropha plant which has good antimicrobial activity for gram negative-positive bacteria. The purpose of this research is to find out the formulation and ability of jatropha leaves extract liquid soap. This type of research is experimental research. working procedures consist of sampling, plant identification; sample processin, extracing, making liquid soap and evaluating liquid dosage form (organoleptic, pH test, high foam, specific gravity). Organolpetic test results of all formulas have a liquid and viscous form. The white base smells like a scented rose, formula 5% wa green, formula 10% was dark brown and formula 15% was dark brown; formula 5%, 10%, 15% special odor of Jatropha leaves. Base pH test 9.7; formula (5%, 10% 15%), 9.6; 9.8;9.5. base foam height tet 61.53 mm, formula (5%, 10% 15%) shich is 70.51mm; 56.81 mm; 76.47 mm. Base specific gravity test 0,79/ml, formula (5%, 10% 15%) namely 1,01g/ml; 1..01g/ml; 1.01g/ml. This study can be concluded that the quality of liquid soap of Jatropha leaves ethanol extract meets the requirements of good liquid soap accordance with the standards set by SNI 06-4085-1996 namely organoleptic tests, pH test, high foam test, and specific gravity test
Copyright (c) 2022 Putri Betania https://creativecommons.org/licenses/by-sa/4.0
FORMULASI BALSEM STICK MINYAK ATSIRI menta piperita, copaifera officinalis (Jacq.) L), DAN gaultheria procumbens L.
Minyak atsiri peppermint, copaiba, dan wintergreen memiliki khasiat sebagai antinyeri dan antiradang yang dapat bermanfaat untuk meringankan gangguan tulang sendi dan otot, dan meredakan sakit kepala serta memberikan rasa nyaman. Minyak atsiri umumnya digunakan dalam bentuk sediaan topikal. Bentuk sediaan balsem yang biasanya lengket memerlukan inovasi baru berupa sediaan balsem stick. Balsem dalam bentuk stick dapat menjadikan penggunaanya lebih praktis, karena dapat langsung diaplikasikan pada kulit tanpa menyebabkan lengket. Penelitian ini bertujuan untuk menghasilkan sediaan balsem stick minyak atsiri yang sesuai dengan syarat mutu fisik. Penelitian ini dilakukan dengan membuat formula balsem stick menjadi tiga formula dengan variasi konsentrasi Cera alba dan adepslanae 10:5: 20:10 dan 30:15sebagai basis yang kemudian dilakukan evaluasi sediaan balsem stick meliputi uji organoleptis, homogenitas, pH, titik lebur, daya sebar, dan daya lekat untuk mendapatkan formula sediaan yang paling baik. Campuran minyak atsiri peppermint, copaiba, dan wintergreen dapat diformulasikan ke dalam sediaan balsem stick dan sediaan dengan Konsentrasi cera alba - Adeps lanae F1 (10% - 5%) dan F2 (20% - 10%) sebagai basis yang menghasilkan sediaan balsem stick dengan mutu fisik yang baik dan sesuai dengan persyaratan balsem stick yang baik.
Copyright (c) 2024 Hairun Nisa https://creativecommons.org/licenses/by-sa/4.0
HUBUNGAN PELAYANAN INFORMASI OBAT DENGAN TINGKAT KEPATUHAN PASIEN HIPERTENSI
Drug information services are very important in supporting the management and use of drugs rationally. Drug information services are very necessary, especially since many patients have not received adequate drug information. The purpose of this study was to see the relationship between drug information services and the level of compliance of hypertensive patients at the Sikumana Health Center in Kupang City. This study is a non-experimental study with a descriptive research design with a prospective approach. The sampling technique used was purposive sampling. Respondents in this study were all patients suffering from high blood pressure (Hypertension) at the Sikumana Health Center in Kupang City with a total of 50 people. Furthermore, the data was analyzed using Kendal's Tau-B correlation analysis with a significance level of p <0.005. Based on the results of statistical tests using Kendal's Tau-B correlation, a significant value of 0.004 was obtained, stating that there was a relationship between drug information services and the level of compliance of hypertensive patients, with a correlation coefficient value of 0.348 with a degree of relationship that is sufficient correlation, so it can be concluded that there is a relationship between drug information services and the level of compliance of hypertensive patients and the degree of relationship that is sufficient correlation.
Compliance, drug information services, relationship, hypertension
Copyright (c) 2021 Amir Kemal https://creativecommons.org/licenses/by-sa/4.0