Perbandingan Efektivitas Paracetamol dan Ibuprofen untuk Terapi Penurun Demam pada Usia 6 Bulan sampai 18 Tahun di RSUD Kota Depok periode Juni 2023 sampai Juni 2024

Authors

  • Mustika Rahayu Politeknik Tiara Bunda
  • Niati Ambarsari Politeknik Tiara Bunda
  • Nur Fadilah Politeknik Tiara Bunda

Keywords:

fever, painful, paracetamol, ibuprofen, Journal of clinical pharmaceutical sciences

Abstract

Fever has been noted as a precursor or characteristic of the disease. Conditions that aggravate fever often result in therapeutic failure or a poor prognosis. This study aims to analyze the comparison of single therapy administration of Paracetamol, Ibuprofen and a combination of both in treating fever and/or pain in patients aged 6 months to 18 years. The results of the study showed that using Ibuprofen alone was better at reducing fever in the first 4 hours than Paracetamol alone, however, the combination therapy of the two was not much different from using Ibuprofen alone. To treat pain accompanied by fever, using Ibuprofen alone has been proven to provide a longer pain-free period compared to using Paracetamol alone, and the combination of the two is not much different from Ibuprofen

Downloads

Download data is not yet available.

References

El-Radhi AS: Fever in common infectious diseases . Clinical Manual of Fever in Children. 2019. 85-140. 10.1007/978-3-319-92336-9_5

Geneva II, Cuzzo B, Fazili T, Javaid W: Normal body temperature: a systematic review . Open Forum Infect Dis. 2019, 6:ofz032. 10.1093/ofid/ofz032

Schmitt BD: Fever phobia: misconceptions of parents about fevers . Am J Dis Child. 1980, 134:176-81.

Blatteis CM: Research in perinatal thermoregulation: recent advances . J Therm Biol. 1983, 8:191-4. 10.1016/0306-4565(83)90102-X

Cahn A, Hepp P: Antifebrin, a new fever remedy [Article in German] . Centralbl Klin Med. 1886, 7:561-4.

Morse HN : About a new method for the preparation of acetamidophenol [Article in German] . Berichte der

deutschen chemischen Gesellschaft. 1878, 1:232-3. 10.1002/cber.18780110151

Connor H: Drug discovery—a history. J R Soc Med. 2005, 98:517-8.

Adams SS: The propionic acids: a personal perspective . J Clin Pharmacol. 1992, 32:317-23. 10.1002/j.1552- 4604.1992.tb03842.x

McIntyre J, Hull D: Comparing efficacy and tolerability of ibuprofen and paracetamol in fever . Arch Dis Child. 1996, 74:164-7. 10.1136/adc.74.2.164

Autret E, Reboul-Marty J, Henry-Launois B, et al.: Evaluation of ibuprofen versus aspirin and paracetamol on efficacy and comfort in children with fever. Eur J Clin Pharmacol. 1997, 51:367-71. 10.1007/s002280050215

Aksoylar S, Akşit S, Cağlayan S, Yaprak I, Bakiler R, Cetin F: Evaluation of sponging and antipyretic medication to reduce body temperature in febrile children. Acta Paediatr Jpn. 1997, 39:215-7. 10.1111/j.1442-200x.1997.tb03584.x 2023 Charde et al. Cureus 15(10): e46907. DOI 10.7759/cureus.46907 6 of 7

Kramer LC, Richards PA, Thompson AM, Harper DP, Fairchok MP: Alternating antipyretics: antipyretic

efficacy of acetaminophen versus acetaminophen alternated with ibuprofen in children. Clin Pediatr (Phila). 2008, 47:907-11. 10.1177/0009922808319967

Hay AD, Costelloe C, Redmond NM, Montgomery AA, Fletcher M, Hollinghurst S, Peters TJ: Paracetamol plus ibuprofen for the treatment of fever in children (PITCH): randomised controlled trial. BMJ. 2008, 337:a1302. 10.1136/bmj.a1302

Hämäläinen ML, Hoppu K, Valkeila E, Santavuori P: Ibuprofen or acetaminophen for the acute treatment of migraine in children: a double-blind, randomized, placebo-controlled, crossover study. Neurology. 1997, 48:103-7. 10.1212/wnl.48.1.103

Harley EH, Dattolo RA: Ibuprofen for tonsillectomy pain in children: efficacy and complications . Otolaryngol Head Neck Surg. 1998, 119:492-6. 10.1016/s0194-5998(98)70107-x

Bradley RL, Ellis PE, Thomas P, Bellis H, Ireland AJ, Sandy JR: A randomized clinical trial comparing the efficacy of ibuprofen and paracetamol in the control of orthodontic pain. Am J Orthod Dentofacial Orthop. 2007, 132:511-7. 10.1016/j.ajodo.2006.12.009

Purssell E: Treating fever in children: paracetamol or ibuprofen? . Br J Community Nurs. 2002, 7:316-20. 10.12968/bjcn.2002.7.6.10477

Goldman RD, Ko K, Linett LJ, Scolnik D: Antipyretic efficacy and safety of ibuprofen and acetaminophen in children. Ann Pharmacother. 2004, 38:146-50. 10.1345/aph.1C391

Erlewyn-Lajeunesse MD, Coppens K, Hunt LP, Chinnick PJ, Davies P, Higginson IM, Benger JR: Randomised controlled trial of combined paracetamol and ibuprofen for fever. Arch Dis Child. 2006, 91:414-6.10.1136/adc.2005.087874

Gazal G, Mackie IC: A comparison of paracetamol, ibuprofen or their combination for pain relief following

extractions in children under general anaesthesia: a randomized controlled trial. Int J Paediatr Dent. 2007, 17:169-77. 10.1111/j.1365-263X.2006.00806.x

Pierce CA, Voss B: Efficacy and safety of ibuprofen and acetaminophen in children and adults: a metaanalysis and qualitative review. Ann Pharmacother. 2010, 44:489-506. 10.1345/aph.1M332

Joshi YM, Sovani VB, Joshi VV, Navrange JR, Benakappa DG, Shivananda P, Sankaranarayanan VS: Comparative evaluation of the antipyretic efficacy of ibuprofen and paracetamol . Indian Pediatr. 1990, 27:803-6.

Carabaño Aguado I, Jiménez López I, López-Cerón Pinilla M, et al.: Antipyretic effectiveness of ibuprofen and paracetamol [Article in Spanish]. An Pediatr (Barc). 2005, 62:117-22. 10.1157/13071307

Autret-Leca E, Gibb IA, Goulder MA: Ibuprofen versus paracetamol in pediatric fever: objective and subjective findings from a randomized, blinded study. Curr Med Res Opin. 2007, 23:2205-11. 10.1185/030079907X223323

Shepherd M, Aickin R: Paracetamol versus ibuprofen: a randomized controlled trial of outpatient analgesia efficacy for paediatric acute

Vivek Charde , Mukesh Sanklecha , Priyank Rajan , Ravi V. Sangoi , Prashanth A , Amisha Palande , Pranav Dighe , Ruchi Kothari , Gaurav Mittal: Comparing the Efficacy of Paracetamol, Ibuprofen, and a Combination of the Two Drugs in Relieving Pain and Fever in the Pediatric Age Group: A Prospective Observational Study. 2023. DOI: 10.7759/cureus.46907

Downloads

Published

2024-08-21

How to Cite

Rahayu, M., Ambarsari, N., & Fadilah, N. (2024). Perbandingan Efektivitas Paracetamol dan Ibuprofen untuk Terapi Penurun Demam pada Usia 6 Bulan sampai 18 Tahun di RSUD Kota Depok periode Juni 2023 sampai Juni 2024. Journal of Pharmacy Tiara Bunda, 1(2), 20–26. Retrieved from https://jurnal.poltektiarabunda.ac.id/index.php/jptb/article/view/103